Extrahepatic tissue concentrations of vitamin K are lower in rats fed a high vitamin E diet
Background:
An adverse hematological interaction between vitamins E and K has been reported, primarily in patients on anticoagulants. However, little is known regarding circulating levels or tissue concentrations of vitamin K in response to vitamin E supplementation. The purpose of this study was to examine the effect of different levels of dietary ?-tocopherol on phylloquinone and menaquinone-4 concentrations, while maintaining a constant intake of phylloquinone, in rat tissues.
Methods:
Male 4-wk old Fischer 344 rats (n = 33) were fed one of 3 diets for 12 wk: control (n = 13) with 30 mg all-rac-?-tocopherol acetate/kg diet; vitamin E-supplemented (n = 10) with 100 mg all-rac-?-tocopherol acetate/kg diet; and vitamin E-restricted (n = 10) with
 
see this hoodia and weight loss directory disclosure…