Enhancing energy and glucose metabolism by disrupting triglyceride synthesis: Lessons from mice lacking DGAT1
Although the ability to make triglycerides is essential for normal physiology, excess accumulation of triglycerides results in obesity and is associated with insulin resistance. Inhibition of triglyceride synthesis, therefore, may represent a feasible strategy for the treatment of obesity and type 2 diabetes. Acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) is one of two DGAT enzymes that catalyze the final reaction in the known pathways of mammalian triglyceride synthesis. Mice lacking DGAT1 have increased energy expenditure and insulin sensitivity and are protected against diet-induced obesity and glucose intolerance. These metabolic effects of DGAT1 deficiency result in part from the altered secretion of adipocyte-derived factors. Studies of DGAT1-deficient mice have helped to provide insights into the mechanisms by which cellular lipid metabolism modulates systemic carbohydrate and insulin metabolism, and a better understanding of how DGAT1 deficiency enhances energy expenditure and insulin sensitivity may identify additional targets or strategies for the treatment of obesity and type 2 diabetes. (more…)

Healthy Trans Fats vs. Unhealthy Trans Fats Revealed
I’m going to talk about something today that most of you have probably never heard…that there is a distinction between good trans fats and bad trans fats. There is some evidence that the good trans can help you with fat loss, muscle building, and even cancer prevention, while the bad trans fats have been shown to cause heart disease, cancer, diabetes, and the general blubbering of your body. (more…)

A Parent’s Guide to Teenage Weight Loss Action …
A Parent’s Guide to Teenage Weight Loss Action Form Yes, I want to learn the techniques on how to help my teen lose weight with these easy to follow, step by step instructions. Please, make sure my package includes the bonuses which come with this special offer absolutely FREE! 101 Ways to Get in Better Shape and Stay that Way A Parent’s (more…)

Know Your Numbers
When you are trying to lose weight, focus is usually on the pounds you weigh, the pounds you have already lost, the pounds you have still to lose, your measurements and possibly your body fat percentage. However, your goal should not just be about losing weight and inches, it should be about leading a healthier […] (more…)

The Truth about Counting Calories
Is it unrealistic to count calories for the rest of your life or is that just part of the price you pay for a better body? You’re about to learn the answers to these questions and discover a simple secret for keeping track of your food intake without having to crunch numbers every day or become a "food fanatic." (more…)